Job Description

Work Location:

Cambridge, Massachusetts

Summary:

Seeking a Contract Research Associate to support analytical research and development activities for pre-clinical and clinical gene editing programs. This lab-based role focuses on routine analytics for various nucleic acid modalities using advanced analytical and molecular biological techniques.

Responsibilities:

• Conduct routine testing for purity, impurity, stability, and identity of mRNA and gRNA molecules, including analysis of capped species, poly A tail, and concentration.
• Collaborate with cross-functional teams to support process development, method development, characterization, comparability, manufacturing, and investigations.
• Utilize chromatographic and electrophoretic separation techniques, such as HPLC/UPLC-UV/FLD, for analytical assessments.
• Apply molecular biological methods, including ELISA and PCR, for sample analysis and data interpretation.
• Support the implementation and automation of sample preparation and data analysis workflows to enhance laboratory efficiency.
• Process, summarize, and interpret analytical data, ensuring accurate and timely reporting of results.
• Engage in continuous learning to quickly adapt to new analytical methods and technologies relevant to gene editing programs.
• Interact and communicate effectively with stakeholders to ensure alignment on project goals and deliverables.

Qualifications:

• BS or MS in Chemistry, Biology, Biochemistry, or related life sciences discipline.
• 3+ years of relevant experience in laboratory settings, with at least 2 years of hands-on industry experience in analytical development or quality control.
• Proficiency with liquid chromatography, plate reader, capillary electrophoresis, UV/VIS/FL spectroscopy, ELISA, and PCR techniques.
• Strong communication skills and ability to work both independently and as part of a team.
• Experience with cell culture is desirable.
• Familiarity with bioinformatics tools and automation for analytical workflows is a plus.
• Demonstrated ability to learn quickly and adapt to new technologies and methodologies.

Published Category:

Analytical & Process Development

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